T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients
نویسندگان
چکیده
منابع مشابه
Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma.
PURPOSE The T cell repertoire in patients with advanced cutaneous T cell lymphoma (CTCL) is significantly contracted despite the presence of relatively normal absolute numbers of T cells. We propose that many normal T cells were being lost in patients with CTCL, with the remaining normal T cells expanding clonally to fill the T cell compartment. T-cell receptor excision circles (TREC) form as a...
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Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...
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The aim of this study was to investigate the prognostic value of 18F-fluoro-deoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) in 37 patients with a history of multiple myeloma (MM) and suspected or confirmed recurrence after stem cell transplantation (SCT). All patients had been heavily pre-treated. Time to progression (TTP) and overall survival (OS) were correlated...
متن کاملRole of Suppressed Immunoglobulins in Outcome of Patients With Multiple Myeloma
Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...
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The role of allogeneic hematopoietic stem cell transplantation (allo-SCT) for multiple myeloma (MM) has not yet been established. We performed allo-SCT on 16 patients with MM in our hospital and an associated center, and retrospectively evaluated its efficacy. The median age at allo-SCT was 47 years. Eight patients underwent allo-SCT as a front-line therapy. Non-myeloablative treatment was prov...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2003
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2003.04482.x